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WHAT IS DELTA PLUS VARIOUS? WHY IS POSSIBILITY MORE DANGEROUS than DELTA? The World Health Organization (WHO) warns, the Delta Plus variant - considered a "descendant" of the Delta variant, with the ability to spread faster, resistant to Covid-19 treatments and challenge the results. fight epidemics in countries, even alarm the scenario of the third wave of infection in the world is approaching. So what is the Delta Plus variant? Why spread more dangerous than Delta? (1) delta plus variant What is delta plus variant? Delta Plus variant (also known as B.1.617.2.1 or AY.1) is a novel variant of the SARS-CoV-2 virus, and is a new mutant version of Delta that was first detected in India in December 2020. Gene sequencing analysis in laboratories in India, The Indian Society of Coronavirus Genomics (INSACOG) reports that the Delta Plus strain is a "variant of concern" with three interesting characteristics: increased transmissibility, stronger binding to lung cell receptors and reduced monoclonal antibody response in COVID-19 therapy. Delta Plus is detected in some countries around the world such as USA, UK, Portugal, Russia, China. South Korea is the latest country to warn of a case of Delta Plus variant in a male patient who had not recently traveled. According to experts, the plus sign (Plus) in Delta Plus refers to the K417N mutation present in the spike protein of the Delta variant. The spike proteins are the part that allows the SARS-CoV-2 virus and other viruses to enter human cells. This mutation is also found in the Beta variant in South Africa, potentially reduce the effectiveness of certain COVID-19 treatments. Since the outbreak of the COVID-19 pandemic in 2020, the SARS-CoV-2 virus has continuously mutated from the original strain, now there is a long list of new variants with "destructive power". stronger. Vietnam and a number of countries around the world used to have effective results in fighting the COVID-19 epidemic, but with the outbreak of Delta and Delta Plus variants, the overall picture has become more complicated, causing serious problems. greater public health threat because of its high infectivity and danger dynamics. Symptoms of Delta Plus Variation Scientists say it is too early to confirm distinct symptoms of Delta Plus variant because of relatively little data. According to early studies, Delta Plus symptoms are similar to those common in patients with the original strain of SARS-CoV-2 virus and other variants, including: (2) Dry cough, Fever, Fatigue, Muscle aches, Sore throat, Conjunctivitis, Loss of taste or smell, Diarrhea, Headache, Chest tightness, Shortness of breath, Loss of voice, Hearing impairment. Notably, the clinical signs caused by the Corona Delta Plus virus strain are very easy to confuse with the common cold, causing many people to subjectively ignore it, increasing the risk of complications or death in patients. patient. Where was Delta Plus first detected? The Delta Plus variant was first recorded in India in 3 states: Maharashtra, Kerala and Madhya Pradesh on April 26, 2021, which has rekindled concerns about a third wave of epidemics in this South Asian country. India's Ministry of Health immediately recommended taking "immediate control measures" where new variants appeared. Suggested measures include avoiding mass gatherings, large-scale testing, contact tracing and accelerating vaccination. To date, the number of people with the Delta Plus variant recorded is still much lower than the Delta variant. In order to have an effect, a variant needs to infect a lot of people and prove infectious, the scientists say, so far Delta Plus has not been able to do that, but it still needs to be studied. research and follow up. Will the Delta Plus variant cause the next pandemic wave? “Based on the available evidence, Delta Plus is not very different from the Delta variant,” said Dr Chandrakant Lahariya, a physician, epidemiologist, vaccine and health system expert in New Delhi. It is a subline of the Delta strain with an additional mutation. The only clinical difference that we know of so far, is that Delta Plus is resistant to monoclonal antibody therapy, which is not a big difference as the therapy itself is research only. and very few people are qualified to do this treatment.” It is not yet possible to predict whether the Delta Plus variant will cause the next pandemic wave, but said Dr Anurag Agarwal, director of the New Delhi-based Institute of Genes and Integrative Biology (IGIB) : “There is no data to date to suggest that Delta Plus will pose a danger to public health. We are closely monitoring and strengthening all protective measures to limit the risk of outbreaks of variants.” Delta Plus is more infectious, lethal or drug resistant? According to the Government of India's COVID-19 Genome Sequencing Agency, the Delta Plus variant has three worrying characteristics: increased infectivity, stronger binding to lung cell receptors, and increased susceptibility to lung cancer. decreased antibody response. Currently, there is no research showing that the new version of Delta can have an effect on the effectiveness of the Covid-19 vaccine - but according to Julian Tang, Professor of Respiratory Science at the University of Leicester (UK). UK) warns Delta Plus can cause "significant vaccine-resistant properties". The nature of COVID-19 vaccines when introduced into the body to train the immune system to recognize the spike protein or its parts - which creates additional mutations of the SARS-CoV-2 virus. However, scientists need more time to isolate and culture the new mutant to monitor its ability to escape immunity, disease severity or increased transmission, etc. How is Delta Plus different from the Delta variant? Unlike Delta, Delta Plus carries an additional mutation called K417N, a mutant protein that has the ability to change the spike protein class and highly infect healthy cells. The “plus (Plus)” in Delta Plus meaningfully refers to the K417N mutation. According to British scientists, Delta Plus divides into at least two groups, including Delta-AY.1 and Delta AY.2. Of these, Delta AY.1 seems to be the most popular. According to scientists, the Delta Plus variant possesses all the characteristics of the Delta variant (first discovered in India) combined with a mutation in the Beta variant (first discovered in South Africa). Delta Plus is considered highly infectious and spreads quickly. It has also been shown to bind more tightly to lung cell receptors and potentially reduce monoclonal antibody responses. The K417N mutation is not entirely new, but it does appear on Delta that makes this strain more deadly. According to Francois Balloux, director of the University of London Genetics Institute (UCL), said: The mutation helps the SARS-CoV-2 virus increase its ability to evade the immune system and spread faster, although the specific level is still unknown. clear. Previously, K417N was found in the Beta, Gamma variant that appeared first in South Africa and Brazil, so this feature is not necessarily a concern. At the same time, K417N is also located in the mutant protein of the virus, which helps to explain the reason for the partial resistance of the Beta strain to the vaccine. The UK Health Authority considers all three strains to be of concern, including the original Delta first discovered in India, as well as Delta Plus, which includes Delta-AY.1 and Delta AY.2. To date, there are 160 variants of the SARS-CoV-2 virus recorded globally. During the process of replicating in cells, the SARS-Cov-2 virus always creates mutations, some mutations make the virus more dangerous, there are mutations that do not make a difference or harm the virus. How dangerous is the Delta Plus variant? The director of the All India Institute of Medical Sciences (AIIM) Randeep Guleria said Delta Plus is so contagious that just walking next to a person infected with this variant without a mask can get COVID-19. The anti-epidemic achievements in the past 2 years are being shaken by "hidden enemies" - mutants Delta Plus or Delta. While Delta variant cases account for 98% of new COVID-19 cases in the UK, 96% in Portugal, More than 20% in Italy and 16% in Belgium, the new Delta Plus version is hindering the efforts that Europe has made over the past 2 months in reducing COVID-19 cases and deaths to the lowest level. from the fall of 2020. The evolution of the covid-19 epidemic The global progress of the COVID-19 epidemic may change in a short time if the measures to prevent and control COVID-19 are not tightened in time. How is the Delta Plus variant spread? “As far as I know, the rate at which a variant spreads cannot be measured by how early it spreads,” said Jacob John, Head of Clinical Virology at the Christian Medical College of India. There is no information that Delta Plus is infecting people who were infected in the first wave, those who were vaccinated, or those who were infected in the second wave. The spread of Delta Plus must be monitored for better understanding.” According to experts, the speed of spread of the SARS-CoV-2 virus is reflected in the development scale of the epidemic, specifically by the R0 index. For the original virus strain in Wuhan, China, the R0 index is only about 2.3-2.5, which means one person can infect 2.3-2.5 other people. For the Alpha strain detected in the UK (Vietnam discovered the Alpha strain during the outbreak in Hai Duong), the R0 index was in the range of 3.4-4.5. However, with this strain of Delta, Delta Plus this time, the level of spread is much faster, overwhelming other strains with an R0 index of about 6.7-7.6, even 9-10. Delta Plus variant still spreads by droplets, these droplets are very small containing viruses, especially, in a closed room environment, this droplet is suspended in the air, slowly falling to the ground, When the sick person breathes out, the virus will hang around and it is very easy to spread the disease. If the space is ventilated, the virus will spread quickly. According to many early studies, the higher the concentration of the virus multiplying in people as well as in the respiratory tract, the greater the ability to spread the disease. Because the degree of spread depends on the concentration of virus in a unit of saliva ejected, the degree of virus penetration into the cell and the duration of the risk of contact with an infected person. With Delta and Delta Plus strains, these factors are very high, so the spread of the disease increases dramatically, especially in enclosed spaces such as industrial parks, factories, churches, karaoke bars, etc. strain delta plus Currently scientists are still actively studying the impact Delta Plus may have on the community. What kind of Covid variants are present around the world? Hitherto, Around the world, researchers have sequenced hundreds of thousands of genomes of the SARS-CoV-2 virus with thousands of variants identified. Most mutations don't make much sense, but there are some that can make the virus more contagious, deadly, or resistant to vaccines and treatments. Accordingly, the World Health Organization (WHO) classified 4 variants into the group of Corona virus variants of concern (VOCs) including: Alpha, Beta, Gamma and Delta, which were first detected in the UK, South Africa, Brazil and the US. India. 1. Alpha Variant The Alpha variant, also known as B.1.1.7, was first discovered in the United Kingdom, and has the ability to spread 70% faster than the original strain. Alpha's arrival marks a strong global outbreak of COVID-19 by the end of 2020. In Vietnam, B.1.1. 7 is the virus strain detected in many current cases and during the outbreak in Hai Duong and Quang Ninh in July 2020. 2. Beta Variant This variant also known as B.1.351, or 501Y.V2, was found in South Africa in early October 2020, contributing to the increase in infections and hospitalizations across South Africa. . According to epidemiologists, the Belta variant is different from the Alpha variant, 1.5 times more infectious, more aggressive, able to evolve and adapt more… January 31, 2021, Vietnam recorded the first case of Belta variant (B.1.351) from a quarantined South African immigration specialist. 3. Gamma variant The Gamma variant, also known as P.1, was discovered on a group of Japanese tourists in January 2021, although it has existed in Brazil since November 2020. In just a short time, P. 1 quickly became the dominant virus strain throughout Brazil and spread terror in many countries around the world. Notably, P.1 is 2.5 times more infectious than the original SARS-CoV-2 virus strain that appeared initially, and its resistance to antibodies is also higher. 4. Delta variant This is a "double mutant" variant also known as B.1.617.2, which was first discovered in India in December 2020. With a remarkable infection rate, the Delta variant is now a virus strain that has spread to more than 130 countries and territories, imposing a burden on the global health system. Worryingly, people infected with the Delta variant had an 85% higher risk of hospitalization than the Alpha variant as well as an increased risk of death, especially those with chronic underlying medical conditions. During the COVID-19 outbreak in Vietnam, Delta variant was first detected in positive cases in HCMC on 18/05/2021. While the Delta variant is threatening the fight against COVID-19 worldwide, the appearance of the Lambda variant is causing many scientists and epidemiologists to express concern about the level of infection and other complications. benefits that viruses can have on humans. Lambda variant was first discovered in Peru in August 2020 and has now spread to 41 countries around the world. The World Health Organization (WHO) has classified Lambda as a “variant of concern” – a strain suspected of being more infectious than the original strain or resistant to vaccines. social distance compliance Compliance with social distance is considered an effective solution to reduce the risk of infection with the SARS-CoV-2 virus. Do Covid-19 vaccines work against Delta? YES! According to recent studies, the COVID-19 vaccines that have been deployed in countries around the world are still completely effective against the Delta variant and protect vaccinated people from severe disease progression. . Because, this strain is not so different from the original virus that it can "dodge" the vaccine shots. current covid-19 vaccines COVID-19 vaccines are completely effective against COVID-19 variants. Recently, on July 21, a study published in the New England Journal of Medicine found that two doses of Pfizer or AstraZeneca's COVID-19 vaccine were as effective at preventing Delta variants as before the variant. Alpha. Specifically, two doses of Pfizer's vaccine were 88% effective in preventing symptomatic cases caused by Delta variant infection and 93.7% Alpha variant. 2 doses of AstraZeneca vaccine protect 74, 5% for the Alpha variant, higher than the initial estimate of 66%. Previously, Public Health England (PHE), the Pfizer vaccine helped reduce the rate of hospitalization by 96%, the AstraZeneca vaccine achieved the rate of 92%. In addition, both vaccines have also been shown to protect against the risk of severe disease progression of more than 90%. The World Health Organization (WHO) and CDC emphasize: A COVID-19 vaccine is a durable shield against the attack and replication of the SARS-CoV-2 virus. In the US, about 97% of people hospitalized with COVID-19 are people who have not been vaccinated against COVID-19. The US CDC shows that people who are vaccinated against COVID-19 are 8 times less likely to contract the virus and develop the disease; The risk of hospitalization, the mortality rate is 25 times lower than those of unvaccinated people. The Delta Plus variant is threatening the world's nearly 2 years of anti-epidemic achievements. Both Delta or Delta plus are "hidden enemies", which could cause the pandemic to return in the near future if countries do not accelerate vaccination programs against COVID-19. At the same time, people need to seriously implement the 5K message to create millions of "steel shields" to repel the epidemic.END=NAM MO SHAKYAMUNI BUDDHA.( 3 TIMES ).GOLDEN MONASTERY=VIETNAMESE BUDDHIST NUN=THE WOMEN OF THE SAKYA CLAN CHAN TANH.AUSTRALIA,SYDNEY.25/8/2021.VIETNAMESE TRANSLATE ENGLISH BY=VIETNAMESE BUDDHIST NUN=THE WOMEN OF THE SAKYA CLAN CHAN TANH.